Caffeine enhancement of chromosomal aberrations induced by thiotepa in bone marrow cells of mice

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Chromosomal aberrations and bone marrow toxicity.

The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell death and so are proximate causes of toxicity when they occur. The micronucleus test which utilizes...

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ژورنال

عنوان ژورنال: Hereditas

سال: 2009

ISSN: 0018-0661

DOI: 10.1111/j.1601-5223.1978.tb00985.x